Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 16/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.39 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187067 | 0.84 | DDR1 (0.61) | DDR1DDR2NPC1L1HSD17B10OPRM1 | |
| SCHEMBL20187192 | 0.75 | DDR1 (0.64) | DDR1DDR2 | |
| Trifluoroacetic Acid SCHEMBL20187130 | 0.75 | DDR1 (0.61) | DDR1DDR2 | |
| Hydrochloric Acid SCHEMBL20187033 | 0.74 | DDR1 (0.63) | DDR1DDR2 | |
| Fluoroacetate SCHEMBL20187131 | 0.72 | DDR1 (0.42) | DDR1DDR2NPC1L1HSD17B10BDKRB2 | |
| SCHEMBL20187075 | 0.70 | DDR1 (0.62) | DDR1DDR2NPC1L1 | |
| SCHEMBL10248209 | 0.69 | OPRK1 (0.51) | NPC1L1HSD17B10OPRM1OPRD1OPRK1 | |
| SCHEMBL10248464 | 0.69 | OPRK1 (0.51) | NPC1L1HSD17B10OPRM1OPRD1OPRK1 | |
| SCHEMBL11879130 | 0.69 | OPRL1 (0.65) | NPC1L1HSD17B10OPRM1OPRD1OPRK1 | |
| SCHEMBL318086 | 0.69 | OPRL1 (0.48) | NPC1L1HSD17B10OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317279-B1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-06 | — | — | US | disclosed |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMAN LA-ROCHE INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA-ROCHE INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885DDR2 2/4885NPC1L1 3430/4885 |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | DDR1 1/4885DDR2 2/4885NPC1L1 3430/4885 |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | DDR1 1/4885DDR2 2/4885NPC1L1 3430/4885 |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | DDR1 1/4885DDR2 2/4885NPC1L1 3430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.