Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 13/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 13/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10248209 | 1.00 | OPRK1 (0.51) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318391 | 0.88 | OPRL1 (0.48) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318086 | 0.88 | OPRL1 (0.48) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318087 | 0.88 | OPRL1 (0.48) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318532 | 0.85 | OPRM1 (0.46) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318533 | 0.85 | OPRM1 (0.46) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL318548 | 0.85 | OPRM1 (0.46) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL9998993 | 0.84 | OPRL1 (0.45) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| SCHEMBL9998646 | 0.83 | OPRM1 (0.46) | OPRK1OPRL1OPRD1OPRM1HSD17B10 | |
| Toluene SCHEMBL318509 | 0.82 | OPRM1 (0.43) | OPRK1OPRL1OPRD1OPRM1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156840-B2 | D2 antagonists, methods of synthesis and methods of use | Altos Therapeutics, LLC (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140350005-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-11-27 | — | — | US | disclosed |
| US-8691836-B2 | D2 antagonists, methods of synthesis and methods of use | Altos Therapeutics, LLC (US) | 2014-04-08 | — | — | US | disclosed |
| US-20120010228-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350005-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | DRD2, DRD3, AVPR2 | OPRK1 29/4885OPRL1 28/4885OPRD1 12/4885 |
| US-20120010228-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | DRD2, DRD3, AVPR2 | OPRK1 29/4885OPRL1 28/4885OPRD1 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.