Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.47 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11595827 | 0.88 | HSD17B10 (0.59) | HSD17B10SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL11507207 | 0.88 | HSD17B10 (0.59) | HSD17B10SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL3068674 | 0.84 | HSD17B10 (0.73) | HSD17B10SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL18353751 | 0.83 | HSD17B10 (0.59) | HSD17B10SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL11880961 | 0.78 | HSD17B10 (0.73) | HSD17B10SLC6A9OPRM1OPRL1OPRK1 | |
| SCHEMBL11593274 | 0.78 | HSD17B10 (0.73) | HSD17B10SLC6A9OPRM1OPRL1OPRK1 | |
| SCHEMBL318959 | 0.78 | HSD17B10 (0.73) | HSD17B10SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL5556794 | 0.78 | HSD17B10 (0.73) | HSD17B10SLC6A9SLC6A5OPRM1OPRL1 | |
| SCHEMBL219618 | 0.78 | HSD17B10 (1.00) | HSD17B10SLC6A9OPRM1OPRL1OPRK1 | |
| SCHEMBL7587764 | 0.78 | HSD17B10 (1.00) | HSD17B10SLC6A9OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849044-B | Triaza-spirodecanones as DDR1 inhibitors | 豪夫迈·罗氏有限公司 | 2021-06-25 | — | — | CN | disclosed |
| EP-3317279-B1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-06 | — | — | US | disclosed |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMAN LA-ROCHE INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA-ROCHE INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | HSD17B10 2768/4885SLC6A9 4234/4885SLC6A5 4172/4885 |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | HSD17B10 2768/4885SLC6A9 4234/4885SLC6A5 4172/4885 |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | HSD17B10 2768/4885SLC6A9 4234/4885SLC6A5 4172/4885 |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | HSD17B10 2768/4885SLC6A9 4234/4885SLC6A5 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.