Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 1.00 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.59 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219618 | 1.00 | HSD17B10 (1.00) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| Ammonia Solution, Strong SCHEMBL1764035 | 0.98 | HSD17B10 (0.97) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL6160546 | 0.98 | HSD17B10 (0.97) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| Ammonia Solution, Strong SCHEMBL8729935 | 0.86 | HSD17B10 (0.74) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL2539061 | 0.85 | OPRM1 (0.77) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL8729938 | 0.85 | HSD17B10 (0.72) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL11880961 | 0.84 | HSD17B10 (0.73) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL11593274 | 0.84 | HSD17B10 (0.73) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL318959 | 0.84 | HSD17B10 (0.73) | HSD17B10OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL3068674 | 0.84 | HSD17B10 (0.73) | HSD17B10OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237890-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | Neotherapeutics, Inc. (US) | 2002-09-11 | — | — | EP | disclosed |
| US-6297226-B1 | TREATING A DISEASE OR A CONDITION IN A MAMMAL TREATABLE BY INHIBITING THE ACTIVITY OF A MONOAMINE OXIDASE | NEOTHERAPEUTICS, INC. | 2001-10-02 | — | — | US | disclosed |
| WO-2001029039-A1 | SYNTHESIS AND METHODS OF USE OF 9-SUBSTITUTED GUANINE DERIVATIVES | NEOTHERAPEUTICS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |