Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 11/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.53 |
| ▸ | PLD2 | O14939 | 3/20 | 0.53 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11880961 | 0.85 | HSD17B10 (0.73) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL3068674 | 0.85 | HSD17B10 (0.73) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL11593274 | 0.85 | HSD17B10 (0.73) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL5556794 | 0.85 | HSD17B10 (0.73) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL219618 | 0.84 | HSD17B10 (1.00) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL7587764 | 0.84 | HSD17B10 (1.00) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| Ammonia Solution, Strong SCHEMBL1764035 | 0.83 | HSD17B10 (0.97) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL6160546 | 0.83 | HSD17B10 (0.97) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL11878143 | 0.81 | HSD17B10 (0.68) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL319470 | 0.81 | HSD17B10 (0.68) | HSD17B10OPRM1OPRL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3829579-B1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S P A (IT) | 2023-08-02 | — | — | EP | disclosed |
| EP-3381896-B1 | BIPHENYL COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2023-01-18 | — | — | EP | disclosed |
| EP-3829579-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | Maria Cecilia Hospital S.p.A. (IT) | 2021-06-09 | — | — | EP | disclosed |
| US-10723742-B2 | Biphenyl compound or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2020-07-28 | — | — | US | disclosed |
| WO-2020021378-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S.P.A. (IT) | 2020-01-30 | — | — | WO | disclosed |
| US-10428049-B2 | TRPA1 modulators | ALGOMEDIX, INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-10428049-B2 | TRPA1 modulators | ALGOMEDIX, INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20190016701-A1 | TRPA1 MODULATORS | ALGOMEDIX, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-20190016701-A1 | TRPA1 MODULATORS | ALGOMEDIX, INC. (US) | 2019-01-17 | — | — | US | disclosed |
| US-20180354960-A1 | NOVEL BIPHENYL COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2018-12-13 | — | — | US | disclosed |
| US-4175129-A | Antiemetic 1-(benzoxazolylalkyl)-piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-20 | — | — | US | disclosed |
| US-4160836-A | Antiemetic 1-(benzothiazolylalkyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-07-10 | — | — | US | disclosed |
| US-4126688-A | ANTIEMETIC 1-(BENZOTRIAZOLYL-ALKYL)-PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-4126687-A | ANTIEMETIC, 1-(BENZIMIDAZOLYL-ALKYL)-PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-11-21 | — | — | US | disclosed |
| US-4110333-A | ANTIEMETIC INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-08-29 | — | — | US | disclosed |
| US-4082755-A | NEUROLEPTIC | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-04-04 | — | — | US | disclosed |
| US-4076821-A | 4,4-Diphenylcycloalkylpiperidines and psychotropic compositions thereof | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JA) | 1978-02-28 | — | — | US | disclosed |
| US-4066772-A | ANTIEMETICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1978-01-03 | — | — | US | disclosed |
| US-4031226-A | ANTIEMETIC, PSYCHOTROPIC | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-06-21 | — | — | US | disclosed |
| US-3996363-A | ANTIDEPRESSANT, ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10723742-B2 | Biphenyl compound or salt thereof | KDM1B, BMI1, HDAC1 | HSD17B10 627/4885OPRM1 4045/4885OPRL1 4419/4885 |
| US-10428049-B2 | TRPA1 modulators | TRPA1, TRPV1, TRPV2 | HSD17B10 3406/4885OPRM1 23/4885OPRL1 8/4885 |
| US-20190016701-A1 | TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | HSD17B10 3406/4885OPRM1 23/4885OPRL1 8/4885 |
| US-20180354960-A1 | NOVEL BIPHENYL COMPOUND OR SALT THEREOF | KDM1B, HDAC1, DOT1L | HSD17B10 763/4885OPRM1 4144/4885OPRL1 4110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.