Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29651147 | 1.00 | L3MBTL1 (0.78) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL15747688 | 0.88 | L3MBTL1 (0.60) | L3MBTL1MEN1KMT2AMAPTHPGD | |
| SCHEMBL13343761 | 0.88 | L3MBTL1 (0.67) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL3169068 | 0.88 | L3MBTL1 (0.64) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL5740608 | 0.88 | L3MBTL1 (1.00) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL12572728 | 0.87 | L3MBTL1 (0.73) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL2882457 | 0.87 | L3MBTL1 (0.73) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL30777140 | 0.86 | L3MBTL1 (0.72) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL10088115 | 0.85 | L3MBTL1 (0.74) | L3MBTL1EPHX1PDE10AHTR6MEN1 | |
| SCHEMBL1520892 | 0.85 | L3MBTL1 (0.70) | L3MBTL1EPHX1PDE10AHTR6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612424-B2 | HPK1 inhibitors and uses thereof | REGOR PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| WO-2023134608-A1 | FUSED RING COMPOUNDS SERVING AS HPK1 INHIBITORS | 微境生物医药科技(上海)有限公司 | 2023-07-20 | — | — | WO | disclosed |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. | 2022-12-08 | — | — | US | disclosed |
| WO-2021000935-A1 | HPK1 INHIBITORS AND USES THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2021-01-07 | — | — | WO | disclosed |
| WO-2017098733-A1 | INDOLE ACETIC ACID DERIVATIVE | 株式会社 東北テクノアーチ | 2017-06-15 | — | — | WO | disclosed |
| WO-2017098731-A1 | 4-PHENYL-4-OXOBUTANOIC ACID DERIVATIVE | 株式会社 東北テクノアーチ | 2017-06-15 | — | — | WO | disclosed |
| US-8563567-B2 | Substituted heterocyclic compounds | ARQULE, INC. (US) | 2013-10-22 | — | — | US | disclosed |
| WO-2011082266-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | ARQULE, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20110160237-A1 | Substituted Heterocyclic Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE | 2010-05-06 | — | — | US | disclosed |
| WO-2010042758-A2 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-04-15 | — | — | WO | disclosed |
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
| WO-2010011864-A2 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | WO | disclosed |
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12612424-B2 | HPK1 inhibitors and uses thereof | NEK11, NEK1, CSNK1A1 | L3MBTL1 2092/4885EPHX1 2462/4885PDE10A 2850/4885 |
| US-20220389037-A1 | HPK1 INHIBITORS AND USES THEREOF | HIPK1, SIK1, PGK1 | L3MBTL1 2199/4885EPHX1 2811/4885PDE10A 3003/4885 |
| US-20100113466-A1 | OXAZOLE-PYRIDAZINE-OXAZOLE ALPHA-HELIX MIMETIC | OXA1L, H1-4, H1-5 | L3MBTL1 1151/4885EPHX1 1621/4885PDE10A 4131/4885 |
| US-20100022549-A1 | ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE | H1-4, H1-5, H1-3 | L3MBTL1 1812/4885EPHX1 2302/4885PDE10A 3959/4885 |
| US-20110160237-A1 | Substituted Heterocyclic Compounds | MKI67, CCNC, NQO1 | L3MBTL1 4509/4885EPHX1 522/4885PDE10A 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.