Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 1/20 | 0.67 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.67 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.67 |
| ▸ | ESR1 | P03372 | 6/20 | 0.64 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.57 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.53 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207027 | 0.93 | TLR2 (0.60) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL20207000 | 0.88 | PTPN11 (0.73) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL20188951 | 0.86 | PTPN11 (0.78) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL20206978 | 0.86 | TLR2 (0.67) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL15557658 | 0.85 | TLR2 (0.91) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL12610198 | 0.82 | TLR2 (0.76) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL12610468 | 0.81 | TLR2 (0.85) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL12610357 | 0.81 | TLR2 (0.85) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL15560260 | 0.81 | TLR2 (1.00) | TLR2TLR1TLR6ESR1PTPN11 | |
| SCHEMBL17069805 | 0.81 | TLR2 (1.00) | TLR2TLR1TLR6ESR1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544952-B1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIV ANTWERPEN (BE) | 2024-11-06 | — | — | EP | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| EP-3544952-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | Universiteit Antwerpen (BE) | 2019-10-02 | — | — | EP | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| WO-2018096088-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018096088-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | ATG4B, ATG7, ATG4A | TLR2 4347/4885TLR1 4091/4885TLR6 3991/4885 |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | ATG4B, ATG7, BECN1 | TLR2 4242/4885TLR1 4090/4885TLR6 3881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.