Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188166 | 0.88 | AURKA (0.44) | AURKAABL1PDGFRBPDGFRA | |
| SCHEMBL30530307 | 0.88 | AURKA (0.44) | AURKAABL1PDGFRBPDGFRA | |
| SCHEMBL30114879 | 0.86 | BCHE (0.46) | AURKAABL1BCR | |
| SCHEMBL20187744 | 0.86 | BCHE (0.46) | AURKAABL1BCR | |
| SCHEMBL21799119 | 0.85 | — | — | |
| SCHEMBL20188725 | 0.84 | MCHR1 (0.54) | ABL1BCR | |
| SCHEMBL30114741 | 0.84 | MCHR1 (0.54) | ABL1BCR | |
| SCHEMBL30530294 | 0.84 | ABL1 (0.54) | ABL1PDGFRBBCRPDGFRA | |
| SCHEMBL21799066 | 0.84 | ABL1 (0.54) | ABL1PDGFRBBCRPDGFRA | |
| SCHEMBL21799072 | 0.83 | RAB9A (0.51) | AURKAABL1PDGFRBBCRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544685-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | Development Center for Biotechnology (TW) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098250-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2018-05-31 | — | — | WO | disclosed |