Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20167294 | 0.88 | APLNR (0.50) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20168252 | 0.88 | APLNR (0.50) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20167297 | 0.88 | APLNR (0.50) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL18247235 | 0.81 | LMNA (0.49) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20190021 | 0.80 | LMNA (0.48) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20189566 | 0.80 | LMNA (0.48) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20189568 | 0.80 | LMNA (0.48) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20191069 | 0.79 | LMNA (0.47) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20187774 | 0.79 | LMNA (0.47) | LMNAALDH1A1HTTSMN1; SMN2TSHR | |
| SCHEMBL20189055 | 0.79 | LMNA (0.47) | LMNAALDH1A1HTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541792-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | Amgen Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |