Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 11/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | SCN1A | P35498 | 2/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL20188018 | 0.79 | SCN5A (0.45) | SCN5ASCN10AKCNH2 | |
| SCHEMBL20189468 | 0.71 | SCN5A (0.46) | SCN5ASCN10AKCNH2SCN1ASCN2A | |
| SCHEMBL18654126 | 0.70 | LTA4H (0.56) | SCN5ASCN10AKCNH2SCN1ASCN2A | |
| SCHEMBL1227164 | 0.68 | CHRM5 (0.52) | SCN5ASCN10AKCNH2SCN1ASCN2A | |
| SCHEMBL1333400 | 0.68 | ABL1 (0.53) | SCN5ASCN10AKCNH2SCN1ASCN2A | |
| SCHEMBL17157363 | 0.68 | SCN5A (0.48) | SCN5ASCN10AKCNH2SCN1ASCN2A | |
| SCHEMBL1242144 | 0.68 | KIF11 (0.52) | SCN5ASCN10AKCNH2SCN1ASCN2A | |
| SCHEMBL18012042 | 0.67 | KIF11 (0.41) | SCN5ASCN1ASCN2AKIF11NISCH | |
| SCHEMBL8103595 | 0.67 | ABL1 (0.54) | SCN5AKIF11PRMT6 | |
| SCHEMBL1742853 | 0.67 | CHRM5 (0.54) | SCN5ASCN10AKCNH2SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188839-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2018098500-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188839-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | SCN5A 8/4885SCN10A 24/4885KCNH2 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.