Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.46 |
| ▸ | ABL1 | P00519 | 9/20 | 0.44 |
| ▸ | BRAF | P15056 | 6/20 | 0.44 |
| ▸ | KIT | P10721 | 5/20 | 0.44 |
| ▸ | BCR | P11274 | 4/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | ABL2 | P42684 | 3/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.44 |
| ▸ | LYN | P07948 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | FGR | P09769 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | NQO2 | P16083 | 2/20 | 0.44 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.44 |
| ▸ | FRK | P42685 | 2/20 | 0.44 |
| ▸ | BLK | P51451 | 2/20 | 0.44 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188084 | 0.84 | ABL1 (0.49) | EGFRABL1BRAFKITBCR | |
| SCHEMBL20188677 | 0.83 | BRAF (0.49) | EGFRABL1BRAFKITBCR | |
| SCHEMBL30114739 | 0.82 | ABL1 (0.47) | EGFRABL1BRAFKITBCR | |
| SCHEMBL21799087 | 0.82 | ABL1 (0.47) | EGFRABL1BRAFKITBCR | |
| SCHEMBL30530293 | 0.77 | RAB9A (0.53) | ABL1BCRLMNAMAPK14F10 | |
| SCHEMBL21799076 | 0.77 | RAB9A (0.53) | ABL1BCRLMNAMAPK14F10 | |
| SCHEMBL20188790 | 0.75 | ABL1 (0.51) | ABL1BCRLMNAMAPK14 | |
| SCHEMBL21799066 | 0.74 | ABL1 (0.54) | EGFRABL1BRAFKITBCR | |
| SCHEMBL30530294 | 0.74 | ABL1 (0.54) | EGFRABL1BRAFKITBCR | |
| SCHEMBL20191064 | 0.73 | ABL1 (0.52) | EGFRABL1BRAFKITBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544685-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | Development Center for Biotechnology (TW) | 2019-10-02 | — | — | EP | disclosed |
| WO-2018098250-A1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEVELOPMENT CENTER FOR BIOTECHNOLOGY (TW) | 2018-05-31 | — | — | WO | disclosed |