SCHEMBL20191359

SCHEMBL20191359

Nc1ncnc2c1nnn2[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ AHCY P23526 13/20 1.00
▸ ADORA2B P29275 1/20 0.65
▸ P2RY12 Q9H244 1/20 0.43
▸ HNMT P50135 1/20 0.42
▸ ADORA3 P0DMS8 1/20 0.41
▸ ADORA2A P29274 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9679135 0.89 AHCY (0.80) AHCYADORA2BADORA3ADORA2A
SCHEMBL14635720 0.83 AHCY (0.71) AHCYADORA2B
SCHEMBL21057423 0.83 AHCY (0.71) AHCYADORA2BADORA3ADORA2A
SCHEMBL13524256 0.81 AHCY (0.67) AHCYADORA2B
SCHEMBL10675784 0.81 AHCY (0.68) AHCYADORA2BP2RY12
SCHEMBL10675799 0.81 AHCY (0.68) AHCYADORA2BP2RY12
SCHEMBL12149497 0.81 AHCY (0.68) AHCYADORA2BADORA3ADORA2A
Aristeromycin SCHEMBL10353291 0.79 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL7534801 0.79 AHCY (1.00) AHCYADORA2B
Aristeromycin SCHEMBL10353292 0.79 AHCY (1.00) AHCYADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210371546-A1 ANTIBODIES TO TICAGRELOR AND METHODS OF USE MEDIMMUNE LTD (GB) 2021-12-02 — — US disclosed
US-10954308-B2 Antibodies to ticagrelor and methods of use MEDIMMUNE LIMITED (GB) 2021-03-23 — — US disclosed
US-10487154-B2 Antibodies to ticagrelor and methods of use MEDIMMUNE LIMITED (GB) 2019-11-26 — — US disclosed
US-20190077882-A1 ANTIBODIES TO TICAGRELOR AND METHODS OF USE MEDIMMUNE LIMITED (GB) 2019-03-14 — — US disclosed
US-9982061-B2 Antibodies to ticagrelor and methods of use MEDIMMUNE LIMITED (GB) 2018-05-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190077882-A1 ANTIBODIES TO TICAGRELOR AND METHODS OF USE NT5C2, GP6, P2RY6 AHCY 213/4885ADORA2B 12/4885P2RY12 9/4885
US-10954308-B2 Antibodies to ticagrelor and methods of use NT5C2, GP6, P2RY6 AHCY 213/4885ADORA2B 12/4885P2RY12 9/4885
US-20210371546-A1 ANTIBODIES TO TICAGRELOR AND METHODS OF USE NT5C2, GP6, P2RY6 AHCY 213/4885ADORA2B 12/4885P2RY12 9/4885
US-10487154-B2 Antibodies to ticagrelor and methods of use NT5C2, GP6, P2RY6 AHCY 213/4885ADORA2B 12/4885P2RY12 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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