Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA8 | P11142 | 4/20 | 0.51 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | GAPDH | P04406 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HBB | P68871 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17406920 | 1.00 | HSPA8 (0.51) | HSPA8HSPA5RXFP1GAPDHHSD17B10 | |
| SCHEMBL6380760 | 0.88 | HSPA8 (0.61) | HSPA8HSPA5RXFP1GAPDHHSD17B10 | |
| SCHEMBL17816352 | 0.78 | ADK (0.64) | SLC29A1 | |
| SCHEMBL18009703 | 0.78 | ADK (0.64) | SLC29A1 | |
| SCHEMBL17800853 | 0.78 | ADK (0.64) | SLC29A1 | |
| SCHEMBL18595743 | 0.78 | ADK (0.64) | SLC29A1 | |
| SCHEMBL1740449 | 0.78 | HSPA5 (0.63) | HSPA8HSPA5RXFP1GAPDHHSD17B10 | |
| SCHEMBL18464362 | 0.75 | ADK (0.57) | HSPA8HSPA5RXFP1ADORA3 | |
| SCHEMBL19837967 | 0.75 | ADK (0.70) | HSPA8HSPA5RXFP1GAPDHHSD17B10 | |
| SCHEMBL17406892 | 0.74 | HSPA8 (0.56) | HSPA8HSPA5RXFP1GAPDHHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981968-B2 | Substituted pyrrolo[2,3-d]pyrimidines for the treatment of cancer and proliferative disorders | NORTHWESTERN UNIVERSITY (US) | 2018-05-29 | — | — | US | disclosed |