HSPA8

Heat shock cognate 71 kDa protein · P11142 · HSPA8 on Sugi Atlas →

5,205 patent compounds predicted against HSPA8, 3,765 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL952636 SCHEMBL952636 0.82 7/20
SCHEMBL952641 SCHEMBL952641 0.82 7/20
SCHEMBL2116061 SCHEMBL2116061 1.00 6/20
SCHEMBL2117317 SCHEMBL2117317 1.00 6/20
SCHEMBL2117400 SCHEMBL2117400 1.00 6/20
SCHEMBL2572253 SCHEMBL2572253 0.95 6/20
SCHEMBL2572254 SCHEMBL2572254 0.95 6/20
SCHEMBL2568779 SCHEMBL2568779 0.83 6/20
SCHEMBL2568783 SCHEMBL2568783 0.83 6/20
SCHEMBL954478 SCHEMBL954478 0.82 6/20
SCHEMBL954479 SCHEMBL954479 0.82 6/20
SCHEMBL2804418 SCHEMBL2804418 0.81 6/20
SCHEMBL1661019 SCHEMBL1661019 0.74 6/20
SCHEMBL1661023 SCHEMBL1661023 0.74 6/20
SCHEMBL1799845 SCHEMBL1799845 0.55 6/20
SCHEMBL3877828 SCHEMBL3877828 0.45 6/20
SCHEMBL2384313 SCHEMBL2384313 0.83 5/20
SCHEMBL2384317 SCHEMBL2384317 0.83 5/20
SCHEMBL952762 SCHEMBL952762 0.82 5/20
SCHEMBL952764 SCHEMBL952764 0.82 5/20

Clinical trials — most relevant to HSPA8 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
OGX-427 in Castration Resistant Prostate Cancer Patients PHASE2COMPLETED
Colchicine for Amyotrophic Lateral Sclerosis PHASE2COMPLETED
17AAG to Treat Kidney Tumors in Von Hippel-Lindau Disease PHASE2COMPLETED
Phase I/II Safety Study of IPI-504 in Relapsed/Refractory Stage IIIb, or Stage IV Non-small Cell Lung Cancer (NSCLC) PHASE1/PHASE2COMPLETED
A Phase 2 Study to Investigate the Clinical Activity of IPI-504 in Patients With Hormone-resistant Prostate Cancer PHASE2COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors PHASE1COMPLETED
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors PHASE1COMPLETED
HS-201, an HSP90 Inhibitor-linked Verteporfin for Detection of Solid Malignancies PHASE1WITHDRAWN
Safety and Pharmacology Study of SNX-5422 in Subjects With Resistant Lung Adenocarcinoma PHASE1COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas PHASE1COMPLETED
Phase I Study of IPI-504 and Docetaxel in Patients With Advanced Solid Tumors PHASE1COMPLETED
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Solid Tumors That Cannot Be Removed By Surgery PHASE1COMPLETED
Safety Study of IPI-504 in Patients With Relapsed and Relapsed Refractory Multiple Myeloma PHASE1COMPLETED
Once or Twice Daily Administration of BIIB021 to Subjects With Advanced Solid Tumors PHASE1COMPLETED
Exercise on Expression of Heat Shock Protein 70 in Arterial Risk nanCOMPLETED
Perfusion-Induced Hyperthermia for Metastatic Carcinoma nanCOMPLETED
Role of Sorcin and Annexin A3 in Breast Cancer Patients nanUNKNOWN
Cardioprotective Benefit of Passive Heat Therapy in Higher-Level Spinal Cord Injury: Safety and Proof of Concept nanUNKNOWN
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) nanRECRUITING
BASE HSP110 : A New Therapeutic Target and a New Marker for Prognosis of Type MSI Colorectal Cancer nanUNKNOWN
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis nanCOMPLETED
Acute Passive Heating in Healthy Older Adults nanCOMPLETED
LncRNA Nicotinamide Nucleotide Transhydrogenase-Antisense RNA1 NNT-AS1 in CRC nanCOMPLETED
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases. nanNOT_YET_RECRUITING
Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia nanRECRUITING
Trial of Nonsurgical Treatment of Intermittent Claudication Due to Femoro-popliteal Disease nanCOMPLETED
Reduced Ventilator-Free Days and Bacterial Colonization of Sub-Glottic Secretions nanWITHDRAWN
Chronic Heat Therapy for Improving Vascular Health nanCOMPLETED
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
Muscle Wasting in Cancer (MWIC) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a HSPA8 binder may also engage these)

ProteinNameSimilarity
A2Q0Z1 1.000 A2Q0Z1 →
Q71U34 1.000 Q71U34 →
P63017 1.000 P63017 →
Q5NVM9 1.000 Q5NVM9 →
P19120 1.000 P19120 →
P19378 1.000 P19378 →
O73885 1.000 O73885 →
Q90473 1.000 Q90473 →
Q9TUG3 1.000 Q9TUG3 →
HSPA2 Heat shock-related 70 kDa protein 2 1.000 landscape →
P10591 1.000 P10591 →
Q01233 1.000 Q01233 →
P14659 1.000 P14659 →
P11147 1.000 P11147 →
P08418 1.000 P08418 →
P10592 1.000 P10592 →
P09446 1.000 P09446 →
P87047 1.000 P87047 →
P17156 1.000 P17156 →
Q05944 1.000 Q05944 →
Q9VG58 1.000 Q9VG58 →
P26413 1.000 P26413 →
Q61696 1.000 Q61696 →
Q9U639 1.000 Q9U639 →
Q27965 1.000 Q27965 →
P22954 1.000 P22954 →
Q9BIS2 1.000 Q9BIS2 →
P0DMW0 1.000 P0DMW0 →
Q4U0F3 1.000 Q4U0F3 →
P0DMW1 1.000 P0DMW1 →