Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016100 | 0.84 | MAP4K4 (0.40) | LMNAMAPK1HTTSMN1; SMN2AURKA | |
| SCHEMBL20119671 | 0.80 | AURKA (0.52) | LMNAMAPK1HTTSMN1; SMN2AURKA | |
| SCHEMBL2019256 | 0.74 | MAP4K4 (0.42) | LMNAMAPK1HTTSMN1; SMN2AURKA | |
| SCHEMBL621253 | 0.74 | CLK4 (0.67) | AURKAAURKBABL1MAP4K4BTK | |
| SCHEMBL2015901 | 0.73 | MAPK1 (0.48) | LMNAMAPK1HTTSMN1; SMN2AURKA | |
| SCHEMBL9609211 | 0.71 | MAPK1 (0.64) | LMNAMAPK1HTTSMN1; SMN2MAPT | |
| SCHEMBL2013612 | 0.70 | PIK3CD (0.41) | LMNAMAPK1HTTSMN1; SMN2AURKA | |
| SCHEMBL2051140 | 0.69 | PIK3CD (0.45) | LMNAMAPK1HTTSMN1; SMN2AURKA | |
| SCHEMBL17933849 | 0.69 | HTT (0.49) | LMNAMAPK1HTTSMN1; SMN2MAP4K4 | |
| SCHEMBL2717143 | 0.69 | MAP4K4 (0.41) | LMNAMAPK1HTTSMN1; SMN2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |