Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 11/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16608553 | 0.88 | CHUK (0.40) | CHUKCREBBPKCNH2DYRK1ADYRK1B | |
| SCHEMBL19114174 | 0.88 | CHUK (0.40) | CHUKCREBBPKCNH2DYRK1ADYRK1B | |
| SCHEMBL19114543 | 0.87 | CHUK (0.35) | CHUKCREBBP | |
| SCHEMBL20193251 | 0.86 | CREBBP (0.33) | CREBBPDYRK1BALK | |
| SCHEMBL20193155 | 0.85 | CHUK (0.38) | CHUKDYRK1A | |
| SCHEMBL20193217 | 0.85 | DYRK1A (0.40) | CHUKDYRK1A | |
| SCHEMBL19114436 | 0.84 | CHUK (0.38) | CHUKKCNH2DYRK1A | |
| SCHEMBL20193179 | 0.84 | CREBBP (0.32) | CHUKCREBBPALK | |
| SCHEMBL20193214 | 0.83 | CHUK (0.41) | CHUKDYRK1A | |
| SCHEMBL20193244 | 0.83 | PIK3CD (0.33) | CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981963-B2 | 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-29 | — | — | US | disclosed |