Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 11/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 7/20 | 0.55 |
| ▸ | C1S | P09871 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 4/20 | 0.44 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KLK1 | P06870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11329583 | 0.79 | PRSS1 (0.59) | PRSS1PRSS3PRSS2C1SF2 | |
| SCHEMBL1172633 | 0.79 | TSHR (0.39) | PRSS1PRSS3PRSS2ACHE | |
| SCHEMBL1172624 | 0.77 | ACHE (0.48) | PRSS1PRSS3PRSS2ACHE | |
| SCHEMBL205947 | 0.77 | ACHE (0.48) | PRSS1PRSS3PRSS2ACHE | |
| SCHEMBL7589533 | 0.75 | TPMT (0.46) | ACHE | |
| Hydrochloric Acid SCHEMBL205946 | 0.74 | ACHE (0.46) | PRSS1PRSS3PRSS2ACHE | |
| Hydrochloric Acid SCHEMBL7596506 | 0.73 | TPMT (0.45) | APEX1ACHE | |
| SCHEMBL20194148 | 0.71 | PRSS1 (0.50) | PRSS1PRSS3PRSS2C1SF2 | |
| SCHEMBL8542393 | 0.71 | PRSS1 (1.00) | PRSS1PRSS3PRSS2C1SF2 | |
| SCHEMBL3600242 | 0.69 | SLC7A5 (0.48) | LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |