Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.50 |
| ▸ | C1S | P09871 | 3/20 | 0.50 |
| ▸ | F2 | P00734 | 6/20 | 0.48 |
| ▸ | PLG | P00747 | 3/20 | 0.48 |
| ▸ | PLAU | P00749 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.42 |
| ▸ | F12 | P00748 | 2/20 | 0.42 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11329583 | 0.85 | PRSS1 (0.59) | PRSS1PRSS3PRSS2C1SF2 | |
| SCHEMBL9313017 | 0.85 | LMNA (0.55) | PRSS1PRSS3PRSS2C1SF2 | |
| SCHEMBL6093793 | 0.76 | PARP1 (0.50) | BLMCA12ALDH1A1CA1CA2 | |
| SCHEMBL62693 | 0.73 | — | — | |
| SCHEMBL63371 | 0.73 | — | — | |
| SCHEMBL13948235 | 0.73 | PRSS1 (0.63) | PRSS1PRSS3PRSS2C1SF2 | |
| SCHEMBL29581511 | 0.71 | CA12 (0.68) | LMNAAPEX1PKMCA12ALDH1A1 | |
| SCHEMBL571808 | 0.71 | CA12 (0.68) | LMNAAPEX1PKMCA12ALDH1A1 | |
| SCHEMBL20194145 | 0.71 | PRSS1 (0.55) | PRSS1PRSS3PRSS2C1SF2 | |
| Hydrochloric Acid SCHEMBL10780490 | 0.70 | ALDH1A1 (0.48) | CA12ALDH1A1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |