SCHEMBL20195102

SCHEMBL20195102

CCn1c(=O)cc(Cl)c2cc(/C(=N/C(C)=N)Nc3ccccc3)ccc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.43
HTT P42858 2/20 0.43
GLA P06280 1/20 0.43
ALDH1A1 P00352 3/20 0.40
NPSR1 Q6W5P4 2/20 0.40
KDM4E B2RXH2 5/20 0.40
KMT2A Q03164 4/20 0.40
MEN1 O00255 3/20 0.40
HPGD P15428 3/20 0.40
LMNA P02545 2/20 0.40
RECQL P46063 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40
RORC P51449 1/20 0.39
TP53 P04637 1/20 0.38
POLB P06746 1/20 0.37
PPARG P37231 1/20 0.37
NCOA1 Q15788 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20354220 0.85 NPSR1 (0.38) MAPTHTTGLAALDH1A1NPSR1
SCHEMBL21549574 0.75 ALDH1A1 (0.38) MAPTHTTGLAALDH1A1NPSR1
SCHEMBL20183578 0.74 KDM4E (0.53) MAPTHTTALDH1A1KDM4EKMT2A
SCHEMBL20183800 0.72 KDM4E (0.52) MAPTHTTALDH1A1KDM4EKMT2A
SCHEMBL20354284 0.71 MAPT (0.46) MAPTHTTALDH1A1KDM4EKMT2A
SCHEMBL20183727 0.71 NPC1 (0.51) MAPTHTTGLAALDH1A1KDM4E
SCHEMBL20183867 0.70 KDM4E (0.40) MAPTHTTGLAALDH1A1KDM4E
SCHEMBL20183773 0.70 CNR2 (0.49) MAPTALDH1A1NPSR1KDM4EKMT2A
SCHEMBL20354222 0.67 KMT2A (0.38) MAPTHTTGLAALDH1A1KDM4E
SCHEMBL20183861 0.67 GRM4 (0.57) MAPTALDH1A1KDM4EKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3327004-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND FUJIFILM CORP (JP) 2020-11-04 EP disclosed
EP-3563851-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR FUJIFILM Corporation (JP) 2019-11-06 EP disclosed
WO-2018124180-A1 ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR 富士フイルム株式会社 2018-07-05 WO disclosed
EP-3327004-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND Fujifilm Corporation (JP) 2018-05-30 EP disclosed