Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18402510 | 0.87 | KDM4E (0.38) | KDM4EL3MBTL1GABRA5ALDH1A1ADRA2A | |
| SCHEMBL1403884 | 0.84 | KDM4E (0.43) | KDM4EL3MBTL1GABRA5ALDH1A1ADRA2A | |
| SCHEMBL2461154 | 0.79 | L3MBTL1 (0.56) | KDM4EL3MBTL1GABRA5ALDH1A1THRB | |
| SCHEMBL1821132 | 0.75 | GBA1 (0.40) | KDM4EL3MBTL1GABRA5ALDH1A1GBA1 | |
| SCHEMBL16787910 | 0.75 | KDM4E (0.45) | KDM4EL3MBTL1ALDH1A1DGAT1MAPT | |
| SCHEMBL22031991 | 0.74 | KDM4E (0.41) | KDM4EGABRA5ALDH1A1GBA1DGAT1 | |
| SCHEMBL1284075 | 0.73 | KDM4E (0.42) | KDM4EGABRA5ALDH1A1ADRA2AADRA2B | |
| SCHEMBL374769 | 0.73 | DGAT1 (0.58) | KDM4EL3MBTL1ALDH1A1DGAT1RAB9A | |
| SCHEMBL30815211 | 0.72 | KDM4E (0.41) | KDM4EL3MBTL1GABRA5ALDH1A1ADRA2A | |
| SCHEMBL156935 | 0.72 | MAPT (0.52) | KDM4EGABRA5ALDH1A1GBA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729447-B1 | POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR | H LUNDBECK AS (DK) | 2018-05-30 | — | — | EP | disclosed |