Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11912104 | 0.78 | MAPT (0.41) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL19647047 | 0.78 | — | — | |
| SCHEMBL13802677 | 0.78 | MAPT (0.41) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL24966963 | 0.78 | MAPT (0.33) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL22695777 | 0.78 | MAPT (0.33) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL14507948 | 0.73 | L3MBTL1 (0.46) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL18294899 | 0.72 | MME (0.32) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL13030819 | 0.71 | — | — | |
| SCHEMBL19647079 | 0.71 | PIK3CD (0.32) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL21378488 | 0.71 | PIK3CD (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327027-B9 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2021-07-07 | — | — | EP | disclosed |
| EP-3327027-B1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | PFIZER (US) | 2021-01-06 | — | — | EP | disclosed |
| EP-3327027-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2018-05-30 | — | — | EP | disclosed |