Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 16/20 | 0.39 |
| ▸ | CNR1 | P21554 | 12/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16535265 | 0.85 | CNR2 (0.39) | CNR2CNR1PGK1NPC1RAB9A | |
| SCHEMBL20197218 | 0.84 | MAPT (0.36) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL20197297 | 0.83 | CYP19A1 (0.35) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL20197472 | 0.83 | CYP1B1 (0.36) | NPC1RAB9ASMN1; SMN2HTTLMNA | |
| SCHEMBL20197267 | 0.80 | C1S (0.34) | NPC1RAB9ASMN1; SMN2HTTLMNA | |
| SCHEMBL20197221 | 0.80 | SREBF2 (0.55) | LMNAMAPTKDM4E | |
| SCHEMBL20197220 | 0.79 | SREBF2 (0.35) | LMNAMAPTRXFP1KDM4E | |
| SCHEMBL20197342 | 0.78 | LMNA (0.37) | NPC1RAB9ASMN1; SMN2HTTLMNA | |
| SCHEMBL20197302 | 0.76 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2HTTLMNA | |
| SCHEMBL16548477 | 0.76 | CNR2 (0.39) | CNR2CNR1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |