Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197186 | 0.92 | HPGD (0.54) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20460485 | 0.87 | NPC1 (0.55) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21516993 | 0.84 | NPC1 (0.51) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16548438 | 0.82 | NPC1 (0.66) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4574293 | 0.81 | HPGD (0.64) | NPC1RAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL6228759 | 0.81 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL3225623 | 0.80 | HPGD (0.55) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13493618 | 0.80 | KDM1A (0.57) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29951948 | 0.80 | KDM1A (0.57) | KDM1AMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16544524 | 0.79 | KDM1A (0.56) | KDM1AMAOANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |