Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 3/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.34 |
| ▸ | ITGAL | P20701 | 2/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | EIF4E | P06730 | 2/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197238 | 0.85 | CYP19A1 (0.44) | KDM4ENPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL16535259 | 0.82 | SMG1 (0.39) | MAPK14SMG1MTORKDM4ENPC1 | |
| SCHEMBL20197301 | 0.81 | KDM4E (0.34) | KDM4ENPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL20197235 | 0.80 | SREBF2 (0.42) | KDM4ESREBF2 | |
| SCHEMBL20197223 | 0.79 | SREBF2 (0.42) | KDM4ESREBF2 | |
| SCHEMBL20197350 | 0.78 | PIM1 (0.41) | SMG1PIK3C3MTORKDM4ECDK2 | |
| SCHEMBL20197304 | 0.78 | CDK2 (0.39) | KDM4ENPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL20197481 | 0.78 | EIF4E (0.37) | KDM4ENPC1CRHBPRAB9ACRHR2 | |
| SCHEMBL16536446 | 0.77 | NMT1 (0.42) | SMG1PIK3C3MTORKDM4ECDK2 | |
| SCHEMBL20197337 | 0.77 | CYP1A2 (0.40) | KDM4ENPC1CRHBPRAB9ACRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |