Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 18/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197223 | 0.87 | SREBF2 (0.42) | SREBF2MAPTATMKDM4ELMNA | |
| SCHEMBL20197238 | 0.86 | CYP19A1 (0.44) | SREBF2KDM4E | |
| SCHEMBL20197249 | 0.84 | SREBF2 (0.43) | SREBF2MAPTATMKDM4ELMNA | |
| SCHEMBL16535861 | 0.82 | SREBF2 (0.48) | SREBF2MAPTATMKDM4ELMNA | |
| SCHEMBL20197301 | 0.80 | KDM4E (0.34) | SREBF2MAPTATMKDM4ELMNA | |
| SCHEMBL20197368 | 0.80 | MAPK14 (0.35) | SREBF2KDM4E | |
| SCHEMBL20197304 | 0.79 | CDK2 (0.39) | MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL20197479 | 0.78 | EIF4E (0.39) | MAPTKDM4EALDH1A1 | |
| SCHEMBL20197337 | 0.77 | CYP1A2 (0.40) | MAPTKDM4EALDH1A1 | |
| SCHEMBL20197159 | 0.76 | CYP19A1 (0.33) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |