Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021190 | 0.92 | POLB (0.50) | FFAR2POLBMEN1KMT2AKCNQ2 | |
| SCHEMBL22095552 | 0.92 | POLB (0.50) | FFAR2POLBMEN1KMT2AKCNQ2 | |
| SCHEMBL22077754 | 0.90 | POLB (0.47) | FFAR2POLBMEN1KMT2AKCNQ2 | |
| SCHEMBL22111715 | 0.90 | POLB (0.47) | FFAR2POLBMEN1KMT2AKCNQ2 | |
| SCHEMBL2018206 | 0.90 | POLB (0.47) | FFAR2POLBMEN1KMT2AKCNQ2 | |
| SCHEMBL2753918 | 0.78 | ABL1 (0.58) | FFAR2POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2019870 | 0.78 | GLS (0.52) | POLBMEN1KMT2AKCNQ2MAPT | |
| SCHEMBL2754075 | 0.77 | POLB (0.51) | POLBMEN1KMT2AKCNQ2L3MBTL1 | |
| SCHEMBL2019259 | 0.77 | HDAC1 (0.48) | FFAR2POLBMAPTSMN1; SMN2GCK | |
| SCHEMBL2754036 | 0.77 | POLB (0.66) | POLBMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402884-A1 | (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2022-12-22 | — | — | US | disclosed |
| US-11420947-B2 | (S)-n-hydroxy-2-(2-(4-methoxyphenyl)butanamido)thiazole-5-carboxamide and pharmaceutically acceptable salts thereof | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2022-08-23 | — | — | US | disclosed |
| US-20210347747-A1 | (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2021-11-11 | — | — | US | disclosed |
| CN-113631158-A | (S) -N-hydroxy-2- (2- (4-methoxyphenyl) butanamido) thiazole-5-carboxamide and pharmaceutically acceptable salts thereof | 转化药物开发有限责任公司 | 2021-11-09 | — | — | CN | disclosed |
| EP-3893863-A1 | <SMALLCAPS/>? ? ?S? ? ? ? ?()-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | TRANSLATIONAL DRUG DEVELOPMENT LLC (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123414-A1 | (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) | 2020-06-18 | — | — | WO | disclosed |
| US-9221773-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-12-29 | — | — | US | disclosed |
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2013-02-21 | — | — | US | disclosed |
| WO-2011079036-A1 | BENZAMIDE DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2011-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402884-A1 | (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | HDAC5, HDAC2, HDAC3 | FFAR2 1287/4885POLB 2734/4885MEN1 4426/4885 |
| US-11420947-B2 | (S)-n-hydroxy-2-(2-(4-methoxyphenyl)butanamido)thiazole-5-carboxamide and pharmaceutically acceptable salts thereof | HDAC5, HDAC2, HDAC3 | FFAR2 1287/4885POLB 2734/4885MEN1 4426/4885 |
| US-20130045982-A1 | BENZAMIDE DERIVATIVES | BAD, BAK1, BRDT | FFAR2 4139/4885POLB 295/4885MEN1 3145/4885 |
| US-20210347747-A1 | (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | HDAC5, HDAC2, HDAC3 | FFAR2 1287/4885POLB 2734/4885MEN1 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.