SCHEMBL2018206

SCHEMBL2018206

CCC(C(=O)Nc1ncc(C(=O)NO)s1)c1ccc(OC)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
HDAC1 Q13547 6/20 0.46
HDAC3 O15379 3/20 0.46
HDAC4 P56524 3/20 0.46
HDAC8 Q9BY41 3/20 0.46
HDAC6 Q9UBN7 3/20 0.46
KCNQ2 O43526 1/20 0.45
FFAR2 O15552 2/20 0.45
GCK P35557 3/20 0.44
CSNK2A2 P19784 1/20 0.43
CSNK2A1 P68400 1/20 0.43
MAPT P10636 1/20 0.43
GLS O94925 1/20 0.43
ABL1 P00519 1/20 0.42
HDAC7 Q8WUI4 2/20 0.42
HDAC2 Q92769 2/20 0.42
HDAC10 Q969S8 2/20 0.42
HDAC11 Q96DB2 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22077754 1.00 POLB (0.47) POLBMEN1KMT2AHDAC1HDAC3
SCHEMBL22111715 1.00 POLB (0.47) POLBMEN1KMT2AHDAC1HDAC3
SCHEMBL2019875 0.90 FFAR2 (0.55) POLBMEN1KMT2AKCNQ2FFAR2
SCHEMBL2019259 0.87 HDAC1 (0.48) POLBHDAC1HDAC3HDAC4HDAC8
SCHEMBL2019870 0.87 GLS (0.52) POLBMEN1KMT2AHDAC1HDAC3
SCHEMBL2021190 0.87 POLB (0.50) POLBMEN1KMT2AKCNQ2FFAR2
SCHEMBL22095552 0.87 POLB (0.50) POLBMEN1KMT2AKCNQ2FFAR2
SCHEMBL2015269 0.86 HDAC1 (0.50) POLBHDAC1HDAC3HDAC4HDAC8
SCHEMBL2016410 0.86 HDAC1 (0.61) POLBMEN1KMT2AHDAC1HDAC3
SCHEMBL2020130 0.84 HDAC1 (0.54) POLBMEN1KMT2AHDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220402884-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT, LLC 2022-12-22 US claimed
US-11420947-B2 (S)-n-hydroxy-2-(2-(4-methoxyphenyl)butanamido)thiazole-5-carboxamide and pharmaceutically acceptable salts thereof TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) 2022-08-23 US claimed
US-20220184040-A1 METHOD OF TREATING MALIGNANT RHABDOID TUMOR OF THE OVARY AND SMALL CELL CANCER OF THE OVARY OF THE HYPERCALCEMIC TYPE TRANSLATIONAL DRUG DEVELOPMENT, LLC 2022-06-16 US claimed
EP-3946326-A1 METHOD OF TREATING MALIGNANT RHABDOID TUMOR OF THE OVARY AND SMALL CELL CANCER OF THE OVARY OF THE HYPERCALCEMIC TYPE TRANSLATIONAL DRUG DEVELOPMENT LLC (US) 2022-02-09 EP claimed
CN-113874013-A Method for treating malignant rhabdoid tumor of ovary and ovarian small cell carcinoma with hypercalcemia 转化药物开发有限责任公司 2021-12-31 CN claimed
US-20210347747-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT, LLC 2021-11-11 US claimed
CN-113631158-A (S) -N-hydroxy-2- (2- (4-methoxyphenyl) butanamido) thiazole-5-carboxamide and pharmaceutically acceptable salts thereof 转化药物开发有限责任公司 2021-11-09 CN claimed
EP-3893863-A1 <SMALLCAPS/>? ? ?S? ? ? ? ?()-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT LLC (US) 2021-10-20 EP claimed
WO-2020198401-A1 METHOD OF TREATING MALIGNANT RHABDOID TUMOR OF THE OVARY AND SMALL CELL CANCER OF THE OVARY OF THE HYPERCALCEMIC TYPE TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) 2020-10-01 WO claimed
WO-2020123414-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT, LLC (US) 2020-06-18 WO claimed
US-9221773-B2 Benzamide derivatives THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2015-12-29 US claimed
US-20130045982-A1 BENZAMIDE DERIVATIVES THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2013-02-21 US claimed
WO-2011079036-A1 BENZAMIDE DERIVATIVES THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2011-06-30 WO claimed
US-20220402884-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT, LLC 2022-12-22 US disclosed
US-20220402884-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT, LLC 2022-12-22 US disclosed
US-20220402884-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF TRANSLATIONAL DRUG DEVELOPMENT, LLC 2022-12-22 US disclosed
US-9221773-B2 Benzamide derivatives THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2015-12-29 US disclosed
US-20130045982-A1 BENZAMIDE DERIVATIVES THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2013-02-21 US disclosed
US-20130045982-A1 BENZAMIDE DERIVATIVES THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2013-02-21 US disclosed
WO-2011079036-A1 BENZAMIDE DERIVATIVES THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) 2011-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220184040-A1 METHOD OF TREATING MALIGNANT RHABDOID TUMOR OF THE OVARY AND SMALL CELL CANCER OF THE OVARY OF THE HYPERCALCEMIC TYPE CRAT, SHMT2, BRDT POLB 4364/4885MEN1 397/4885KMT2A 83/4885
US-20220402884-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HDAC5, HDAC2, HDAC3 POLB 2734/4885MEN1 4426/4885KMT2A 45/4885
US-11420947-B2 (S)-n-hydroxy-2-(2-(4-methoxyphenyl)butanamido)thiazole-5-carboxamide and pharmaceutically acceptable salts thereof HDAC5, HDAC2, HDAC3 POLB 2734/4885MEN1 4426/4885KMT2A 45/4885
US-20130045982-A1 BENZAMIDE DERIVATIVES BAD, BAK1, BRDT POLB 295/4885MEN1 3145/4885KMT2A 1317/4885
US-20210347747-A1 (S)-N-HYDROXY-2-(2-(4-METHOXYPHENYL)BUTANAMIDO)THIAZOLE-5-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HDAC5, HDAC2, HDAC3 POLB 2734/4885MEN1 4426/4885KMT2A 45/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.