Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 20/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TDO2 | P48775 | 1/20 | 0.55 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20199014 | 0.95 | IDO1 (0.55) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL21538779 | 0.93 | IDO1 (0.55) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL20090615 | 0.92 | IDO1 (0.61) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL19679829 | 0.90 | IDO1 (0.70) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL145811 | 0.90 | IDO1 (0.70) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL145812 | 0.90 | IDO1 (0.70) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL22187873 | 0.89 | IDO1 (0.56) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL20198887 | 0.89 | IDO1 (0.54) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL20199008 | 0.89 | IDO1 (0.52) | IDO1CYP3A4CYP2C9TDO2IDO2 | |
| SCHEMBL22187859 | 0.88 | IDO1 (0.54) | IDO1CYP3A4CYP2C9TDO2IDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370766-B2 | Sulfonyl amidine as indoleamine-2,3-dioxygenase inhibitor, and preparation method therefor and use thereof | SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD. (CN) | 2022-06-28 | — | — | US | disclosed |
| US-11168078-B2 | Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2021-11-09 | — | — | US | disclosed |
| US-11168078-B2 | Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2021-11-09 | — | — | US | disclosed |
| US-20210070742-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | FOCHON BIOSCIENCES, LTD. (CN) | 2021-03-11 | — | — | US | disclosed |
| US-20210070742-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | FOCHON BIOSCIENCES, LTD. (CN) | 2021-03-11 | — | — | US | disclosed |
| US-20200207728-A1 | SULFONYL AMIDINE AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI LONGWOOD BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-07-02 | — | — | US | disclosed |
| EP-3560914-A1 | SULFONYL AMIDINE AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Longwood Biopharmaceuticals Co., Ltd. (CN) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018095432-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11370766-B2 | Sulfonyl amidine as indoleamine-2,3-dioxygenase inhibitor, and preparation method therefor and use thereof | IDO1, IDO2, INMT | IDO1 1/4885CYP3A4 412/4885CYP2C9 525/4885 |
| US-20210070742-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, TST | IDO1 1/4885CYP3A4 362/4885CYP2C9 167/4885 |
| US-20200207728-A1 | SULFONYL AMIDINE AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | IDO1, IDO2, INMT | IDO1 1/4885CYP3A4 412/4885CYP2C9 525/4885 |
| US-11168078-B2 | Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase | IDO1, IDO2, TST | IDO1 1/4885CYP3A4 362/4885CYP2C9 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.