Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20199189 | 0.91 | IDO1 (0.47) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL19881740 | 0.85 | ALDH1A1 (0.46) | IDO1LMNAALDH1A1MAPTTP53 | |
| SCHEMBL145200 | 0.85 | IDO1 (0.51) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL30865861 | 0.85 | IDO1 (0.51) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL145201 | 0.85 | IDO1 (0.51) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL30448914 | 0.84 | IDO1 (0.49) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL30449652 | 0.84 | IDO1 (0.49) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL147069 | 0.84 | IDO1 (0.49) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL147068 | 0.84 | IDO1 (0.49) | IDO1LMNAALDH1A1MAPTGAA | |
| SCHEMBL20198881 | 0.84 | IDO1 (0.46) | IDO1LMNAALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018095432-A1 | SULFOXIMINE, SULFONIMIDAMIDE, SULFONDIIMINE AND DIIMIDOSULFONAMIDE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2, 3-DIOXYGENASE | SHANGHAI FOCHON PHARMACEUTICAL CO., LTD. (CN) | 2018-05-31 | — | — | WO | disclosed |