Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 17/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20203299 | 0.89 | TRPA1 (0.49) | TRPA1RAB9AKMT2A | |
| SCHEMBL20203383 | 0.88 | TRPA1 (0.50) | TRPA1KMT2A | |
| SCHEMBL23718270 | 0.88 | TRPA1 (0.52) | TRPA1 | |
| SCHEMBL20203239 | 0.81 | TRPA1 (0.54) | TRPA1 | |
| SCHEMBL20203409 | 0.79 | TRPA1 (0.52) | TRPA1 | |
| SCHEMBL20203241 | 0.75 | RXFP1 (0.39) | TRPA1 | |
| SCHEMBL20203276 | 0.74 | TRPA1 (0.41) | TRPA1 | |
| SCHEMBL23718276 | 0.73 | TRPA1 (0.50) | TRPA1KMT2A | |
| SCHEMBL22210245 | 0.72 | TRPA1 (0.38) | TRPA1 | |
| SCHEMBL20203209 | 0.70 | TRPA1 (0.65) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544979-B1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| WO-2018096159-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-31 | — | — | WO | disclosed |