Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2420906 | 0.77 | KDM4E (0.58) | ALDH1A1KDM4ESMN1; SMN2METDYRK1A | |
| SCHEMBL31735817 | 0.77 | KDM4E (0.58) | ALDH1A1KDM4ESMN1; SMN2METDYRK1A | |
| SCHEMBL2267586 | 0.75 | ALDH1A1 (0.75) | ALDH1A1KDM4ESMN1; SMN2CYP1A2DYRK1A | |
| SCHEMBL23116158 | 0.75 | KDM4E (0.55) | ALDH1A1KDM4ESMN1; SMN2CYP1A2MET | |
| SCHEMBL750158 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KDM4ESMN1; SMN2CYP1A2DYRK1A | |
| SCHEMBL2263427 | 0.73 | HTT (0.64) | SMN1; SMN2CYP1A2METCDK2MEN1 | |
| SCHEMBL31601848 | 0.72 | DYRK1A (0.51) | ALDH1A1KDM4ESMN1; SMN2DYRK1ADYRK2 | |
| SCHEMBL24155930 | 0.72 | KDM4E (0.51) | ALDH1A1KDM4ESMN1; SMN2CYP1A2MET | |
| SCHEMBL2695540 | 0.72 | KDM4E (0.47) | ALDH1A1KDM4ESMN1; SMN2METKMT2A | |
| SCHEMBL22744857 | 0.71 | ALDH1A1 (0.75) | ALDH1A1KDM4ESMN1; SMN2CYP1A2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322790-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-10-12 | — | — | US | disclosed |
| US-20230322790-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2023-10-12 | — | — | US | disclosed |
| US-20210188852-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2018098499-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188852-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | ALDH1A1 916/4885KDM4E 2066/4885SMN1; SMN2 334/4885 |
| US-20230322790-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | ALDH1A1 916/4885KDM4E 2066/4885SMN1; SMN2 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.