Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20204839 | 0.82 | PBRM1 (0.51) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL21246198 | 0.80 | PBRM1 (0.67) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL4029828 | 0.80 | PBRM1 (0.67) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL20204958 | 0.80 | PBRM1 (0.57) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL4029825 | 0.80 | PBRM1 (0.67) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL7372877 | 0.76 | PBRM1 (0.71) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL17232878 | 0.76 | PBRM1 (0.71) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL23773692 | 0.74 | ALDH1A1 (0.54) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL6156793 | 0.74 | PBRM1 (0.58) | PBRM1GPR84NR4A2CREBBPALDH1A1 | |
| SCHEMBL50742 | 0.73 | PBRM1 (1.00) | PBRM1GPR84NR4A2CREBBPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098473-A1 | REAGENTS AND METHODS FOR ANALYSIS OF PROTEINS AND METABOLITES TARGETED BY COVALENT PROBES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |