Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 7/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CEL | P19835 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207840 | 0.94 | CYP2D6 (0.42) | CYP2D6CYP1A2CYP2C19MOGAT2CEL | |
| SCHEMBL20204601 | 0.90 | CYP2D6 (0.39) | CYP2D6CYP1A2CYP2C19HTR1DIDO1 | |
| SCHEMBL20204827 | 0.84 | CYP2D6 (0.43) | CYP2D6CYP1A2CYP2C19HTR1DIDO1 | |
| SCHEMBL20201906 | 0.81 | TAAR1 (0.37) | SLC6A2SLC6A4SLC6A3CEL | |
| SCHEMBL20204607 | 0.80 | TYR (0.41) | CYP2D6CYP1A2CYP2C19HTR1DIDO1 | |
| SCHEMBL12062354 | 0.79 | HTR1D (0.42) | CYP2D6CYP1A2CYP2C19HTR1DIDO1 | |
| SCHEMBL21513937 | 0.79 | TRPV1 (0.43) | CYP2D6CYP1A2CYP2C19HTR1DIDO1 | |
| SCHEMBL20207843 | 0.78 | SLC6A4 (0.35) | MOGAT2HTR1DSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20207510 | 0.76 | CYP2D6 (0.40) | CYP2D6CYP1A2CYP2C19HTR1DIDO1 | |
| SCHEMBL20207811 | 0.75 | SIGMAR1 (0.58) | HTR1DSLC6A4SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098209-A1 | AMINO SULFONYL COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |