Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.79 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.79 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.79 |
| ▸ | ABL1 | P00519 | 13/20 | 0.75 |
| ▸ | BCR | P11274 | 12/20 | 0.75 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.75 |
| ▸ | SRC | P12931 | 6/20 | 0.72 |
| ▸ | PRKCA | P17252 | 5/20 | 0.72 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.72 |
| ▸ | PRKCG | P05129 | 1/20 | 0.72 |
| ▸ | PRKCB | P05771 | 1/20 | 0.72 |
| ▸ | PRKCH | P24723 | 1/20 | 0.72 |
| ▸ | PRKCI | P41743 | 1/20 | 0.72 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.72 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.72 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.72 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.72 |
| ▸ | ABL2 | P42684 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11927767 | 0.90 | PDGFRA (0.83) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL14979753 | 0.89 | PDGFRA (0.79) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL14979773 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL29416038 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL20204854 | 0.87 | ABL1 (0.72) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL20998651 | 0.87 | ABL1 (0.83) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL14979759 | 0.86 | PDGFRA (0.77) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL9763 | 0.86 | ABL1 (1.00) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL1430 | 0.84 | ABL1 (1.00) | MAPK8MAPK9MAPK10ABL1BCR | |
| SCHEMBL9197 | 0.84 | ABL1 (1.00) | MAPK8MAPK9MAPK10ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11789025-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-10969394-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| US-20210072254-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | DANA-FARBER CANCER INSTITUTE, INC. | 2021-03-11 | — | — | US | disclosed |
| US-20190346454-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | DANA-FARBER CANCER INSTITUTE, INC. | 2019-11-14 | — | — | US | disclosed |
| WO-2018098473-A1 | REAGENTS AND METHODS FOR ANALYSIS OF PROTEINS AND METABOLITES TARGETED BY COVALENT PROBES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10969394-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | PTMS, SRMS, HSP90B1 | MAPK8 3032/4885MAPK9 4002/4885MAPK10 3263/4885 |
| US-11789025-B2 | Reagents and methods for analysis of proteins and metabolites targeted by covalent probes | PTMS, SRMS, HSP90B1 | MAPK8 3032/4885MAPK9 4002/4885MAPK10 3263/4885 |
| US-20210072254-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | PTMS, SRMS, HSP90B1 | MAPK8 3032/4885MAPK9 4002/4885MAPK10 3263/4885 |
| US-20190346454-A1 | Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes | PTMS, SRMS, HSP90B1 | MAPK8 3032/4885MAPK9 4002/4885MAPK10 3263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.