Quinacrine

Quinacrine

SCHEMBL20205

CCN(CC)CCC[C@H](C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP2 O75604 4/20 1.00
TP53 P04637 3/20 1.00
CYP3A4 P08684 3/20 1.00
CASP1 P29466 3/20 1.00
CASP7 P55210 3/20 1.00
HBB P68871 3/20 1.00
HSD17B10 Q99714 3/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2D6 P10635 2/20 1.00
TSHR P16473 2/20 1.00
BRCA1 P38398 2/20 1.00
HIF1A Q16665 2/20 1.00
NPC1 O15118 1/20 1.00
PRNP P04156 1/20 1.00
CHRM2 P08172 1/20 1.00
CHRM4 P08173 1/20 1.00
ABCB1 P08183 1/20 1.00
HTR1A P08908 1/20 1.00
CHRM5 P08912 1/20 1.00
ADRA2A P08913 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinacrine SCHEMBL29363141 1.00 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL19225 1.00 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL29717736 1.00 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL17704776 1.00 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL1817364 1.00 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL33693 0.99 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL30153780 0.99 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL15061349 0.99 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL162379 0.99 USP2 (1.00) USP2TP53CYP3A4CASP1CASP7
Quinacrine SCHEMBL28651594 0.99 USP2 (0.98) USP2TP53CYP3A4CASP1CASP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3626 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240398801-A1 TREATMENT OF LEUKEMIA BASED ON LEUKEMIA HIERARCHY IN A PATIENT UNIVERSITY HEALTH NETWORK (CA) 2024-12-05 US claimed
WO-2024085332-A1 ANTIBODY-BOUND METAL-ORGANIC FRAMEWORK AND ANTICANCER COMPOSITION COMPRISING SAME 울산과학기술원 2024-04-25 WO claimed
WO-2023164252-A1 ISOTHERMAL NUCLEIC ACID DETECTION ASSAYS AND USES THEREOF TRUSTEES OF BOSTON UNIVERSITY (US) 2023-08-31 WO claimed
US-20230241057-A1 COMPOUNDS FOR THE PREVENTION, TREATMENT AND DIAGNOSIS OF THROMBI UNIVERSITE PARIS 13 PARIS-NORD (FR) 2023-08-03 US claimed
WO-2023050018-A1 TREATMENT OF LEUKEMIA BASED ON LEUKEMIA HIERARCHY IN A PATIENT UNIVERSITY HEALTH NETWORK (CA) 2023-04-06 WO claimed
EP-4157282-A1 COMPOUNDS FOR THE PREVENTION, TREATMENT AND DIAGNOSIS OF THROMBI Institut National de la Santé et de la Recherche Médicale (INSERM) (FR) 2023-04-05 EP claimed
WO-2021239905-A1 COMPOUNDS FOR THE PREVENTION, TREATMENT AND DIAGNOSIS OF THROMBI INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2021-12-02 WO claimed
CN-112745832-A Method for preparing fluorescent anti-counterfeiting material 大连理工大学 2021-05-04 CN claimed
CN-110227061-B Nanogel containing platinum nanoparticles, and preparation method and application thereof 中国医学科学院基础医学研究所 2021-01-29 CN claimed
WO-2020242217-A1 LIPOSOME COMPRISING GLUTATHIONE-S-TRANSFERASE AND PROTEIN HAVING CAPACITY TO BIND TO TARGET CELL OR TARGET PROTEIN, AND USE THEREOF 울산과학기술원 2020-12-03 WO claimed
CN-1655817-A Oxygenating agents for enhancing host responses to microbial infections EXPONENTIAL BIOTHERAPIES INC (US) 2005-08-17 CN claimed
EP-1519750-A2 OXYGENATING AGENTS FOR ENHANCING HOST RESPONSES TO MICROBIAL INFECTIONS Exponential Biotherapies, Inc. (US) 2005-04-06 EP claimed
WO-2003082392-A2 OXYGENATING AGENTS FOR ENHANCING HOST RESPONSES TO MICROBIAL INFECTIONS EXPONENTIAL BIOTHERAPIES, INC. (US) 2003-10-09 WO claimed
CN-1359288-A Improved method of transport across an adaptable semi-permeable barrier IDEA AG (DE) 2002-07-17 CN claimed
JP-2001527390-A 2001-12-25 JP claimed
EP-1011655-A1 INHIBITORS OF LEADERLESS PROTEIN EXPORT Ciblex Corporation (US) 2000-06-28 EP claimed
CN-1252716-A Inhibitors of leaderless protein export CIBLEX CORP (US) 2000-05-10 CN claimed
US-5827681-A Rapid detection and drug sensitivity of malaria UNIVERSITY TECHNOLOGY CORPORATION (US) 1998-10-27 US claimed
WO-1998037880-A1 INHIBITORS OF LEADERLESS PROTEIN EXPORT CIBLEX CORPORATION (US) 1998-09-03 WO claimed
EP-0003583-B1 COMPOSITIONS FOR CYTOCHEMICAL INVESTIGATION, THEIR USE AND METHOD FOR THE DETECTION OF STEROID HORMONE RECEPTORS IN HUMAN TISSUES Lee, Sin Hang (US) 1981-12-02 EP claimed