Quinacrine

Quinacrine

SCHEMBL162379

CCN(CC)CCC[C@H](C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12.Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Quinacrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.98
CHRM4 known ✓ P08173 1/20 0.98
HTR1A known ✓ P08908 1/20 0.98
CHRM5 known ✓ P08912 1/20 0.98
ADRA2A known ✓ P08913 1/20 0.98
CHRM1 known ✓ P11229 1/20 0.98
ADRA2B known ✓ P18089 1/20 0.98
ADRA2C known ✓ P18825 1/20 0.98
CHRM3 known ✓ P20309 1/20 0.98
DRD1 known ✓ P21728 1/20 0.98
ACHE known ✓ P22303 1/20 0.98
SLC6A2 known ✓ P23975 1/20 0.98
HRH2 known ✓ P25021 1/20 0.98
ADRA1D known ✓ P25100 1/20 0.98
HTR2A known ✓ P28223 1/20 0.98
OPRM1 known ✓ P35372 1/20 0.98
DRD3 known ✓ P35462 1/20 0.98
SCN1A known ✓ P35498 1/20 0.98
SLC6A3 known ✓ Q01959 1/20 0.98
KCNH2 known ✓ Q12809 1/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Quinacrine SCHEMBL15061349 1.00 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL498442 1.00 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL33693 1.00 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL30153780 1.00 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL25334547 0.99 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL7147115 0.99 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL30416460 0.99 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL450737 0.99 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL7147117 0.99 USP2 (1.00) USP2KDM4EMEN1LMNATP53
Quinacrine SCHEMBL162378 0.99 USP2 (1.00) USP2KDM4EMEN1LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1766 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111630026-A Sustained release pharmaceutical formulations and methods of treatment 道格拉斯制药有限公司 2020-09-04 CN claimed
EP-2801060-A2 METHODS AND APPARATUS FOR HIGH PERFORMANCE DESIGN OF A PROJECT Skidmore Owings & Merrill LLP (US) 2014-11-12 EP claimed
WO-2013103463-A2 METHODS AND APPARATUS FOR HIGH PERFORMANCE DESIGN OF A PROJECT SKIDMORE, OWINGS & MERRILL LLP (US) 2013-07-11 WO claimed
EP-2475805-A1 SOLUTION AND PROCESS FOR ACTIVATING THE SURFACE OF A SEMICONDUCTIVE SUBSTRATE Alchimer (FR) 2012-07-18 EP claimed
WO-2011029860-A1 SOLUTION AND PROCESS FOR ACTIVATING THE SURFACE OF A SEMICONDUCTIVE SUBSTRATE ALCHIMER (FR) 2011-03-17 WO claimed
JP-4217772-B2 2009-02-04 JP claimed
WO-2008127549-A1 NEGATIVE-WORKING IMAGEABLE ELEMENTS AND METHODS OF USE EASTMAN KODAK COMPANY (US) 2008-10-23 WO claimed
JP-2000516279-A 2000-12-05 JP claimed
EP-0917549-A1 AQUEOUS BONDING COMPOSITION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1999-05-26 EP claimed
WO-1998006775-A1 AQUEOUS BONDING COMPOSITION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-02-19 WO claimed
CN-114117061-B River facies knowledge graph back-pushing method based on data mining and tree structure 南京信息工程大学 2024-07-16 CN disclosed
WO-2024144455-A1 COMPOSITIONS AND METHODS FOR TREATING PARKINSON'S DISEASE MOTIGENIX SINGAPORE PTE. LTD. (SG) 2024-07-04 WO disclosed
US-20240216414-A1 Antiviral Agents and Nucleoside Analogs for Treatment of Zika Virus UNIV EMORY (US) 2024-07-04 US disclosed
US-12024511-B2 Substituted imidazo[1,2-a]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof SHANGHAI FUDAN-ZHANGJIANG BIO-PHARMACEUTICAL CO., LTD. (CN) 2024-07-02 US disclosed
US-20240185567-A1 SYSTEM AND METHOD FOR OUTCOME EVALUATIONS ON HUMAN IVF-DERIVED EMBRYOS ZHANG KANG (US) 2024-06-06 US disclosed
EP-0314009-A2 Functionalized conductive polymers and their use in diagnostic devices MILES INC. (US) 1989-05-03 EP disclosed
US-4797187-A COACERVATION OF CATIONS THE DOW CHEMICAL COMPANY (US) 1989-01-10 US disclosed
EP-0234467-A3 ELECTRODELESS HETEROGENEOUS POLYPYRROLE COMPOSITE The B.F. GOODRICH Company (US) 1988-05-04 EP disclosed
US-4661443-A FORMATION OF INITIAL NH2-TERMINAL DIPEPTIDES AND TRIPEPTIDES HOFFMANN-LA ROCHE INC. (US) 1987-04-28 US disclosed
EP-0169995-A2 A high yield process for preparing beta-lactam antibiotics having a high purity degree IBI- Istituto Biochimico Italiano Giovanni Lorenzini S.p.A. (IT) 1986-02-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12024511-B2 Substituted imidazo[1,2-a]pyridin-2-ylamine compounds, and pharmaceutical compositions and methods of use thereof JAK1, JAK2, JAK3 CHRM2 1394/4885CHRM4 2630/4885HTR1A 662/4885
US-20240216414-A1 Antiviral Agents and Nucleoside Analogs for Treatment of Zika Virus SAMHD1, PNP, NUDT1 CHRM2 3532/4885CHRM4 2569/4885HTR1A 560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.