Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20069601 | 0.89 | DPP4 (0.49) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL20147384 | 0.88 | DPP4 (0.48) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL20158744 | 0.86 | DPP4 (0.47) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL20148001 | 0.81 | ADRB2 (0.47) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL20205887 | 0.81 | RET (0.47) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL20147901 | 0.80 | RET (0.44) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL21651944 | 0.79 | RET (0.44) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL25499853 | 0.78 | DPP4 (0.48) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL25502319 | 0.77 | DPP4 (0.50) | DPP4ADRB2ALDH1A1HTTRET | |
| SCHEMBL20147407 | 0.75 | DPP4 (0.46) | DPP4ADRB2ALDH1A1HTTRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | DPP4 1963/4885ADRB2 3956/4885ALDH1A1 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.