Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205886 | 0.89 | DPP4 (0.48) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20147384 | 0.89 | DPP4 (0.48) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL25502319 | 0.88 | DPP4 (0.50) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20158744 | 0.87 | DPP4 (0.47) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20069608 | 0.84 | ADRB2 (0.49) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20069533 | 0.82 | ADRB2 (0.47) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20069529 | 0.81 | ALDH1A1 (0.45) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20069607 | 0.81 | ADRB2 (0.46) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20068812 | 0.81 | RET (0.48) | DPP4ALDH1A1ADRB2HTTRET | |
| SCHEMBL20069536 | 0.80 | RET (0.47) | DPP4ALDH1A1ADRB2HTTRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018071454-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ANDREWS STEVEN W (US) | 2018-04-19 | — | — | WO | disclosed |