Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27629931 | 0.80 | PIK3CD (0.34) | PIK3CDPOLBCYP2D6CYP2C19 | |
| SCHEMBL22305813 | 0.78 | PIK3CD (0.33) | PIK3CDPOLB | |
| SCHEMBL24114607 | 0.78 | L3MBTL1 (0.33) | PIK3CDPOLB | |
| SCHEMBL28707490 | 0.78 | TSHR (0.39) | CYP2D6CYP2C19 | |
| SCHEMBL24846367 | 0.76 | PIK3CD (0.32) | PIK3CDPOLB | |
| SCHEMBL23676017 | 0.76 | PIK3CD (0.32) | PIK3CDPOLB | |
| SCHEMBL15424797 | 0.76 | CA12 (0.33) | PIK3CDPOLB | |
| SCHEMBL6729529 | 0.74 | PIK3CD (0.52) | PIK3CDPOLBCYP2D6CYP2C19 | |
| SCHEMBL24846915 | 0.73 | PIK3CD (0.31) | PIK3CD | |
| SCHEMBL21307514 | 0.73 | PIK3CD (0.47) | PIK3CDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10682419-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2020-06-16 | — | — | US | disclosed |
| US-20180147291-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS, INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180147291-A1 | PRODRUGS OF PEPTIDE EPOXY KETONE PROTEASE INHIBITORS | PREP, VIP, PEPD | PIK3CD 3864/4885POLB 4109/4885CYP2D6 439/4885 |
| US-10682419-B2 | Prodrugs of peptide epoxy ketone protease inhibitors | PREP, VIP, PEPD | PIK3CD 3864/4885POLB 4109/4885CYP2D6 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.