Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 6/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | DUT | P33316 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765009 | 0.89 | GRM2 (0.43) | GRM2DUTDCPSHTR1ASLC6A2 | |
| SCHEMBL24153920 | 0.86 | SCN9A (0.43) | GRM2SCN9AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL20376236 | 0.86 | GRM2 (0.45) | GRM2SCN9AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL18374090 | 0.85 | HCRTR2 (0.39) | GRM2SYKHTR1ASLC6A2SLC6A4 | |
| SCHEMBL765039 | 0.85 | SCN9A (0.44) | GRM2SCN9ASLC6A4 | |
| SCHEMBL20201895 | 0.82 | SLC6A2 (0.53) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10196592 | 0.82 | ACHE (0.49) | SYKSLC6A2SLC6A4 | |
| SCHEMBL13096912 | 0.82 | HTR2A (0.45) | GRM2SCN9ADUTDHFRDCPS | |
| SCHEMBL21325101 | 0.82 | GRM2 (0.44) | GRM2SCN9ADUTDHFRDCPS | |
| SCHEMBL20204766 | 0.79 | SLC6A4 (0.43) | SCN9AHTR1ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018128720-A1 | URACIL CONTAINING COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098208-A1 | NITROGEN RING LINKED DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |