Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207090 | 0.73 | HTT (0.40) | MAPK1ALDH1A1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL2776999 | 0.69 | — | — | |
| SCHEMBL2878722 | 0.63 | — | — | |
| SCHEMBL16232044 | 0.62 | — | — | |
| SCHEMBL13406334 | 0.62 | ALDH1A1 (0.43) | MAPK1ALDH1A1L3MBTL1KDM4ECYP1A2 | |
| SCHEMBL20206779 | 0.60 | — | — | |
| SCHEMBL13007576 | 0.59 | SMN1; SMN2 (0.40) | MAPK1ALDH1A1L3MBTL1CYP1A2NSD2 | |
| SCHEMBL26975118 | 0.59 | KMT2A (0.37) | ALDH1A1KDM4ECYP1A2CYP2C19KMT2A | |
| SCHEMBL10826305 | 0.59 | ALDH1A1 (0.41) | MAPK1ALDH1A1L3MBTL1KDM4ECYP1A2 | |
| SCHEMBL9653630 | 0.59 | NPSR1 (0.49) | MAPK1ALDH1A1L3MBTL1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |