Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | RPA1 | P27694 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20206754 | 0.73 | MAPK1 (0.35) | KDM4ECYP1A2CYP2C19DAOALDH1A1 | |
| SCHEMBL20206755 | 0.68 | POLB (0.32) | POLB | |
| SCHEMBL14734455 | 0.62 | MEN1 (0.34) | KDM4EALDH1A1SMN1; SMN2MAPK1KMT2A | |
| SCHEMBL8508802 | 0.60 | HTT (0.43) | HTTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL13548267 | 0.59 | GLA (0.45) | HTTKDM4EALDH1A1SMN1; SMN2POLB | |
| SCHEMBL19365954 | 0.59 | — | — | |
| SCHEMBL4421374 | 0.59 | HTT (0.39) | HTTKDM4EALDH1A1USP2POLB | |
| SCHEMBL15427229 | 0.58 | L3MBTL1 (0.51) | HTTALDH1A1TNKS2SMN1; SMN2 | |
| SCHEMBL17551856 | 0.58 | MAPT (0.50) | HTTCYP1A2CYP2C19ALDH1A1POLB | |
| SCHEMBL9621372 | 0.57 | KDM4E (0.32) | KDM4EALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |