Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366297 | 0.79 | SYK (0.48) | EPHX2PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL20064064 | 0.78 | FFAR4 (0.45) | EPHX2FFAR4HTR1ASLC6A2SLC6A3 | |
| SCHEMBL6423139 | 0.77 | PDE4A (0.59) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL20204758 | 0.75 | SYK (0.48) | EPHX2PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL13091309 | 0.75 | DUT (0.44) | PDE4DPDE4BPDE4APDE4CPTGS1 | |
| SCHEMBL7360316 | 0.75 | CSNK2A1 (0.44) | EPHX2PDE4BPDE4AFFAR4CSNK2A1 | |
| SCHEMBL12696905 | 0.75 | CSNK2A1 (0.63) | EPHX2PDE4BPDE4AFFAR4CSNK2A1 | |
| SCHEMBL7845194 | 0.75 | TRPV1 (0.43) | EPHX2PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7361842 | 0.75 | FFAR4 (0.46) | EPHX2PDE4BFFAR4 | |
| SCHEMBL20190365 | 0.73 | CSNK2A1 (0.50) | PDE4BCSNK2A1DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |