Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.35 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68550 | 0.87 | ALDH1A1 (0.44) | CYP2C9GRM2ACHECYP1A2L3MBTL1 | |
| SCHEMBL18374087 | 0.87 | CYP2C9 (0.45) | CYP2C9GRM2ACHEPPARATSHR | |
| SCHEMBL13104096 | 0.86 | CYP2C9 (0.47) | CYP2C9ACHEPPARATSHRTDP1 | |
| SCHEMBL20207653 | 0.86 | MRGPRX4 (0.43) | CYP2C9GRM2ACHEHTR1ASLC6A2 | |
| SCHEMBL10203384 | 0.81 | CYP2C9 (0.44) | CYP2C9ACHEPPARATSHRTDP1 | |
| SCHEMBL17815713 | 0.81 | MAPT (0.49) | CYP2C9ACHETDP1CYP1A2PPARG | |
| SCHEMBL17815980 | 0.80 | CYP2C9 (0.45) | CYP2C9TSHRSMN1; SMN2HTR1AL3MBTL1 | |
| SCHEMBL17815717 | 0.77 | SYK (0.47) | CYP2C9PPARAPPARGARSYK | |
| SCHEMBL20208352 | 0.77 | CYP2C9 (0.43) | CYP2C9PPARATSHRTDP1TTR | |
| SCHEMBL257497 | 0.77 | HTT (0.50) | ACHETSHRTDP1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018128720-A1 | URACIL CONTAINING COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-07-12 | — | — | WO | disclosed |
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |