Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.84 |
| ▸ | TAS2R14 | Q9NYV8 | 10/20 | 0.61 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14546179 | 0.92 | APLNR (1.00) | APLNRTAS2R14LMNAPTPN1PTGES | |
| SCHEMBL15721328 | 0.83 | APLNR (0.83) | APLNRTAS2R14LMNAPTPN1PTGES | |
| SCHEMBL15721326 | 0.81 | APLNR (0.78) | APLNRTAS2R14LMNAPTGESTAS2R8 | |
| SCHEMBL18254268 | 0.80 | APLNR (0.77) | APLNRTAS2R14LMNAPTPN1PTGES | |
| SCHEMBL27083378 | 0.78 | TAS2R14 (0.72) | TAS2R14PKMPTGESTAS2R8CXCR3 | |
| SCHEMBL15721343 | 0.77 | APLNR (0.71) | APLNRTAS2R14LMNAPTGESTAS2R8 | |
| SCHEMBL1278748 | 0.77 | TAS2R14 (1.00) | TAS2R14PTGESTAS2R8CXCR3 | |
| SCHEMBL2513385 | 0.77 | TAS2R14 (0.70) | TAS2R14PTPN1PTGESTAS2R8CXCR3 | |
| SCHEMBL27503924 | 0.76 | ESR1 (0.54) | APLNRLMNA | |
| SCHEMBL11609 | 0.76 | APLNR (0.71) | APLNRTAS2R14PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |