Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 18/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207252 | 0.94 | APLNR (0.69) | APLNR | |
| SCHEMBL22537211 | 0.92 | APLNR (0.70) | APLNR | |
| SCHEMBL22537175 | 0.90 | APLNR (0.72) | APLNR | |
| SCHEMBL20207282 | 0.90 | APLNR (0.72) | APLNR | |
| SCHEMBL20207342 | 0.89 | APLNR (0.58) | APLNR | |
| SCHEMBL20207625 | 0.89 | APLNR (0.58) | APLNR | |
| SCHEMBL20207353 | 0.85 | APLNR (0.54) | APLNR | |
| SCHEMBL20207444 | 0.84 | APLNR (0.65) | APLNR | |
| SCHEMBL20207593 | 0.82 | APLNR (0.67) | APLNR | |
| SCHEMBL20207490 | 0.82 | APLNR (0.71) | APLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |