Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 10/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21767131 | 0.83 | HRH3 (0.39) | HRH3GSK3AGSK3BKMT2APTGS1 | |
| SCHEMBL21767099 | 0.83 | HRH3 (0.39) | HCRTR1HCRTR2HRH3GSK3AGSK3B | |
| SCHEMBL20187951 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2HRH3MEN1LMNA | |
| SCHEMBL20189237 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2HRH3MEN1LMNA | |
| SCHEMBL20187955 | 0.80 | HCRTR1 (0.44) | HCRTR1HCRTR2HRH3MEN1LMNA | |
| SCHEMBL1965055 | 0.79 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL8366845 | 0.79 | HCRTR1 (0.64) | HCRTR1HCRTR2 | |
| SCHEMBL16423223 | 0.71 | HCRTR2 (0.56) | HCRTR1HCRTR2GSK3AGSK3BMEN1 | |
| SCHEMBL22537213 | 0.70 | RAB9A (0.56) | MEN1KMT2A | |
| SCHEMBL19302146 | 0.68 | APLNR (0.46) | MEN1LMNATSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541805-B1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC (US) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |