Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PER2 | O15055 | 6/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20188086 | 0.77 | PER2 (0.39) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20188090 | 0.77 | PER2 (0.39) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL20189429 | 0.77 | PER2 (0.39) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10587336 | 0.76 | CHRM2 (0.45) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL22889747 | 0.75 | APLNR (0.32) | APLNR | |
| SCHEMBL11671322 | 0.73 | CHRM2 (0.38) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5331770 | 0.71 | CHRM2 (0.47) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL4338414 | 0.71 | CHRM2 (0.47) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL16918345 | 0.70 | PER2 (0.44) | PER2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1303658 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018097945-A1 | HETEROARYL-SUBSTITUTED TRIAZOLES AS APJ RECEPTOR AGONISTS | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |