Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 1/20 | 0.68 |
| ▸ | ALDH1A3 | P47895 | 10/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24155459 | 0.80 | SCN5A (0.56) | SCN5AALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL16246668 | 0.78 | ALDH1A3 (0.77) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NPC1 | |
| SCHEMBL18427020 | 0.76 | SCN5A (0.52) | SCN5AALDH1A3ALDH1A1ALDH1A2NPC1 | |
| SCHEMBL13325768 | 0.75 | ALDH1A3 (1.00) | ALDH1A3ALDH1A1ALDH1A2SLC2A1NPC1 | |
| SCHEMBL12056714 | 0.75 | SCN5A (0.54) | SCN5AALDH1A3ALDH1A1MAP3K5MCHR1 | |
| SCHEMBL161950 | 0.75 | RAB9A (0.49) | SCN5AALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL16872714 | 0.74 | SCN5A (0.47) | SCN5AALDH1A3ALDH1A1ALDH1A2SLC2A1 | |
| SCHEMBL2118968 | 0.74 | SCN5A (0.53) | SCN5AALDH1A1MCHR1NPC1RAB9A | |
| SCHEMBL18080888 | 0.74 | SCN5A (0.53) | SCN5AALDH1A1MCHR1NPC1RAB9A | |
| SCHEMBL8812209 | 0.74 | SCN5A (0.53) | SCN5AALDH1A3ALDH1A1MAP3K5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210188839-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. | 2021-06-24 | — | — | US | disclosed |
| WO-2018098500-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210188839-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | SCN5A 8/4885ALDH1A3 810/4885ALDH1A1 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.