SCHEMBL20209330

SCHEMBL20209330

CNCC1CCCN1c1ccnc(NC(C)c2ccccc2)n1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 18/20 0.51
LCK P06239 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20209434 0.89 IDH1 (0.52) IDH1LCK
SCHEMBL20209174 0.89 IDH1 (0.52) IDH1LCK
SCHEMBL30123272 0.88 IDH1 (0.52) IDH1LCK
SCHEMBL20209264 0.88 IDH1 (0.52) IDH1LCK
SCHEMBL30122768 0.88 IDH1 (0.52) IDH1LCK
SCHEMBL20209255 0.87 IDH1 (0.50) IDH1LCK
SCHEMBL20209684 0.87 IDH1 (0.50) IDH1LCK
SCHEMBL20209260 0.86 IDH1 (0.48) IDH1
SCHEMBL30123177 0.83 IDH1 (0.47) IDH1LCK
SCHEMBL20187397 0.83 IDH1 (0.51) IDH1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018095344-A1 ISOCITRATE DEHYDROGENASE (IDH) INHIBITOR SHANGHAI METON PHARMACEUTICAL CO., LTD (CN) 2018-05-31 WO disclosed